Tuesday, April 30, 2013

Prep Baseball: Unearned runs carry Dakota past Forreston

FORRESTON ? No matter how much someone is dealing, sometimes a win just isn?t in the cards.

Forreston pitcher Nick Ludwig didn?t give up an earned run in seven innings, but Dakota scored five runs in the first, which proved to be just enough.

The Cardinals lost 5-4 Monday and fell one game behind both Dakota and Aquin in the NUIC East.

?He was pitching really well,? Forreston coach Kyle Zick said. ?We?ve just got to be able to back him up. Unfortunately, we weren?t able to do that.?

Forreston (8-6, 5-2) committed four errors in the first inning, which led to two-run hits for Dakota (6-5, 6-1) by Tayler Burns and Drew Zellmer.

?This is one that hurts him because he pitched so well,? Zick said. ?You give up zero earned and Dakota did all the right things. Those mental mistakes put a lot of pressure on us.?

Ludwig finished with five strikeouts, allowed one walk and four hits ? three were given up in the first inning ? and faced just 21 batters after Dakota?s early rally.

?I just kept throwing my high and inside fastball,? Ludwig said. ?Then they started catching on and I threw curveballs and change-ups.

?But Dakota?s got some good hitters.?

Dakota struggled with consistency at the plate and also found itself in troubles similar to Forreston?s during the bottom of the second.

Winning pitcher Brandon Lizer had two strikeouts that inning, but back-to-back uncaught strike threes allowed those batters to get on base and helped the Cardinals score two runs. Ethan Groom?s RBI single with the bases loaded put Forreston within two runs of tying the game.

A fielding error in the fifth inning, followed by a passed ball and a wild pitch, allowed Ludwig?s groundout to bring Andrew Beasley to score Forreston?s fourth run.

?All four of those runs shouldn?t have happened.? Dakota coach Britton Kauffman said. ?My gut the whole game was like ?don?t lose this.?

?We were just a step behind defensively and the hitting has got to come along.?

Lizer struck out 10, allowed just one walk and surrendered four hits and two earned runs.

?He did a great job keeping us off-balance,? Zick said. ?It was a great pitching performance for both Lizer and Nick.

?That score doesn?t really reflect how great it was. We just came up on the short side because we compounded our mistakes where Dakota didn?t.?
?

Source: http://www.journalstandard.com/sports/x91993484/Prep-Baseball-Unearned-runs-carry-Dakota-past-Forreston?rssfeed=true

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Monday, April 29, 2013

How would you like your assistant -- Human or Robotic?

How would you like your assistant -- Human or Robotic? [ Back to EurekAlert! ] Public release date: 29-Apr-2013
[ | E-mail | Share Share ]

Contact: Jason Maderer
maderer@gatech.edu
404-385-2966
Georgia Institute of Technology

Roboticists are currently developing machines that have the potential to help patients with caregiving tasks, such as housework, feeding and walking. But before they reach the care recipients, assistive robots will first have to be accepted by healthcare providers such as nurses and nursing assistants. Based on a Georgia Institute of Technology study, it appears that they may be welcomed with open arms depending on the tasks at hand.

More than half of healthcare providers interviewed said that if they were offered an assistant, they preferred it to be a robotic helper rather than a human. However, they don't want robots to help with everything. They were very particular about what they wanted a robot to do, and not do. Instrumental activities of daily living (IDALs), such as helping with housework and reminding patients when to take medication, were acceptable. But activities daily living (ADL) tasks, especially those involving direct, physical interactions such as bathing, getting dressed and feeding people, were considered better for human assistants.

The findings will be presented April 27- May 2 at the ACM SIGCHI Conference on Human Factors in Computing Systems in Paris, France.

"One open question was whether healthcare providers would reject the idea of robotic assistants out of fear that the robots would replace them in the workplace," said Tracy Mitzner, one of the study's leaders and the associate director of Georgia Tech's Human Factors and Aging Laboratory. "This doesn't appear to be a significant concern. In fact, the professional caregivers we interviewed viewed robots as a way to improve their jobs and the care they're able to give patients."

For instance, nurses preferred a robot assistant that could help them lift patients from a bed to a chair. They also indicated that robotic assistants could be helpful with some medical tasks such as checking vitals.

"Robots aren't being designed to eliminate people. Instead, they can help reduce physical demands and workloads," Mitzner said. "Hopefully, our study helps create guidelines for developers and facilitates deployment into the healthcare industry. It doesn't make sense to build robots that won't be accepted by the end user."

This study complements the lab's prior research that found older people are generally willing to accept help from robots. Much like the current research, their preferences depended on the task. Participants said they preferred robotic help over human help for chores such as cleaning the kitchen and doing laundry. Getting dressed and suggesting medication were tasks viewed as better suited for human assistants.

###

To view research by other Georgia Tech faculty members at SIGCHI, visit http://chi.gatech.edu.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


How would you like your assistant -- Human or Robotic? [ Back to EurekAlert! ] Public release date: 29-Apr-2013
[ | E-mail | Share Share ]

Contact: Jason Maderer
maderer@gatech.edu
404-385-2966
Georgia Institute of Technology

Roboticists are currently developing machines that have the potential to help patients with caregiving tasks, such as housework, feeding and walking. But before they reach the care recipients, assistive robots will first have to be accepted by healthcare providers such as nurses and nursing assistants. Based on a Georgia Institute of Technology study, it appears that they may be welcomed with open arms depending on the tasks at hand.

More than half of healthcare providers interviewed said that if they were offered an assistant, they preferred it to be a robotic helper rather than a human. However, they don't want robots to help with everything. They were very particular about what they wanted a robot to do, and not do. Instrumental activities of daily living (IDALs), such as helping with housework and reminding patients when to take medication, were acceptable. But activities daily living (ADL) tasks, especially those involving direct, physical interactions such as bathing, getting dressed and feeding people, were considered better for human assistants.

The findings will be presented April 27- May 2 at the ACM SIGCHI Conference on Human Factors in Computing Systems in Paris, France.

"One open question was whether healthcare providers would reject the idea of robotic assistants out of fear that the robots would replace them in the workplace," said Tracy Mitzner, one of the study's leaders and the associate director of Georgia Tech's Human Factors and Aging Laboratory. "This doesn't appear to be a significant concern. In fact, the professional caregivers we interviewed viewed robots as a way to improve their jobs and the care they're able to give patients."

For instance, nurses preferred a robot assistant that could help them lift patients from a bed to a chair. They also indicated that robotic assistants could be helpful with some medical tasks such as checking vitals.

"Robots aren't being designed to eliminate people. Instead, they can help reduce physical demands and workloads," Mitzner said. "Hopefully, our study helps create guidelines for developers and facilitates deployment into the healthcare industry. It doesn't make sense to build robots that won't be accepted by the end user."

This study complements the lab's prior research that found older people are generally willing to accept help from robots. Much like the current research, their preferences depended on the task. Participants said they preferred robotic help over human help for chores such as cleaning the kitchen and doing laundry. Getting dressed and suggesting medication were tasks viewed as better suited for human assistants.

###

To view research by other Georgia Tech faculty members at SIGCHI, visit http://chi.gatech.edu.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-04/giot-hwy042913.php

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Replenish The Concept Of Setting Up New Business With The ...

One who wants to get the higher thought for elaborating its business in Malaysia can?t ever think of doing so without utilizing the service of one or another personal loan company. That?s why it ought to simply plan for getting top class financial assistance to get the cheapest loan deal. This idea will definitely help to arrange the business in a effectively way.

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Did you enjoy this post? Why not leave a comment below and continue the conversation, or subscribe to my feed?and get articles like this delivered automatically to your feed reader.

Source: http://successfulfinancialstrategy.blogcashbiz.com/560/replenish-the-concept-of-setting-up-new-business-with-the-malaysia-based-mostly-personal-loan-company/

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First Data names JPMorgan executive Bisignano as CEO

* Nadal beats fellow Spaniard Almagro 6-4 6-3 * Wins eighth Barcelona title in nine years (Updates with details, quotes) April 28 (Reuters) - Rafa Nadal became the first player to win four titles this year when he defeated fellow Spaniard Nicolas Almagro 6-4 6-3 to win the Barcelona Open for the eighth time in nine years on Sunday. Since returning from a seven-month absence with a left knee injury in February, the world number five has reached the final at all six events he has played, his Barcelona triumph adding to the victories in Sao Paulo, Acapulco and Indian Wells. "I'm very happy. ...

Source: http://news.yahoo.com/first-data-names-jpmorgan-executive-bisignano-ceo-202603090.html

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Sunday, April 28, 2013

Facebook Sees Increase In Parse Signups, Tells Developers ?No Plans To Change How App Data Is Used?

Screen Shot 2013-04-27 at 2.00.17 PMDespite developers grumbling that they would ditch Parse's mobile app backend service now that it's been bought by Facebook, Parse CEO Ilya Suhkar tells me signups spiked 9.4x and fewer clients are leaving than before. Meanwhile, to calm fears about Facebook spying on Parse app data, the company issued the statement "We currently have no plans to make any changes to how Parse app data is used."

Source: http://feedproxy.google.com/~r/Techcrunch/~3/cr7GA3OLTaE/

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Turtle genome analysis sheds light on turtle ancestry and shell evolution

Apr. 28, 2013 ? From which ancestors have turtles evolved? How did they get their shell? New data provided by the Joint International Turtle Genome Consortium, led by researchers from RIKEN in Japan, BGI in China, and the Wellcome Trust Sanger Institute in the UK provides evidence that turtles are not primitive reptiles but belong to a sister group of birds and crocodiles. The work also sheds light on the evolution of the turtle's intriguing morphology and reveals that the turtle's shell evolved by recruiting genetic information encoding for the limbs.

Turtles are often described as evolutionary monsters, with a unique body plan and a shell that is considered to be one of the most intriguing structures in the animal kingdom.

"Turtles are interesting because they offer an exceptional case to understand the big evolutionary changes that occurred in vertebrate history," explains Dr. Naoki Irie, from the RIKEN Center for Developmental Biology, who led the study.

Using next-generation DNA sequencers, the researchers from 9 international institutions have decoded the genome of the green sea turtle and Chinese soft-shell turtle and studied the expression of genetic information in the developing turtle.

Their results published in Nature Genetics show that turtles are not primitive reptiles as previously thought, but are related to the group comprising birds and crocodilians, which also includes extinct dinosaurs. Based on genomic information, the researchers predict that turtles must have split from this group around 250 million years ago, during one of the largest extinction events ever to take place on this planet.

"We expect that this research will motivate further work to elucidate the possible causal connection between these events," says Dr. Irie.

The study also reveals that despite their unique anatomy, turtles follow the basic embryonic pattern during development. Rather than developing directly into a turtle-specific body shape with a shell, they first establish the vertebrates' basic body plan and then enter a turtle-specific development phase. During this late specialization phase, the group found traces of limb-related gene expression in the embryonic shell, which indicates that the turtle shell evolved by recruiting part of the genetic program used for the limbs.

"The work not only provides insight into how turtles evolved, but also gives hints as to how the vertebrate developmental programs can be changed to produce major evolutionary novelties." explains Dr. Irie.

Another unexpected finding of the study was that turtles possess a large number of olfactory receptors and must therefore have the ability to smell a wide variety of substances. The researchers identified more than 1000 olfactory receptors in the soft-shell turtle, which is one of the largest numbers ever to be found in a non-mammalian vertebrate.

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Story Source:

The above story is reprinted from materials provided by RIKEN, via AlphaGalileo.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Zhuo Wang, Juan Pascual-Anaya, Amonida Zadissa, Wenqi Li, Yoshihito Niimura, Zhiyong Huang, Chunyi Li, Simon White, Zhiqiang Xiong, Dongming Fang, Bo Wang, Yao Ming, Yan Chen, Yuan Zheng, Shigehiro Kuraku, Miguel Pignatelli, Javier Herrero, Kathryn Beal, Masafumi Nozawa, Qiye Li, Juan Wang, Hongyan Zhang, Lili Yu, Shuji Shigenobu, Junyi Wang, Jiannan Liu, Paul Flicek, Steve Searle, Jun Wang, Shigeru Kuratani, Ye Yin, Bronwen Aken, Guojie Zhang, Naoki Irie. The draft genomes of soft-shell turtle and green sea turtle yield insights into the development and evolution of the turtle-specific body plan. Nature Genetics, 2013; DOI: 10.1038/ng.2615

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_science/~3/8zHOVHrvis0/130428144848.htm

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Boston bombing interrogation: Will prosecutors have a Miranda problem?

The government has cited public safety in its decision to question Dzhokhar Tsarnaev, the alleged Boston Marathon bomber, for 16 hours before reading him his Miranda rights. Legal experts differ on whether that's OK.

By Ron Scherer,?Staff writer / April 26, 2013

The US Marshals Service said Friday that Dzhokhar Tsarnaev, charged in the Boston Marathon bombing, had been moved from a Boston hospital to the federal medical center at Devens, about 40 miles west of the city.

Elise Amendola/AP

Enlarge

The Federal Bureau of Investigation questioned alleged Boston Marathon bomber Dzhokhar Tsarnaev for 16 hours over two sessions without telling him he had the right to remain silent and to not implicate himself.

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The FBI?s legal rationale for the long questioning period: It needed to find out if public security was at risk, perhaps because more bombs were planted or a collaborator was on the loose.

Was the government?s questioning excessive? And might it have some impact on the case?

Judging by the responses of some criminal defense lawyers, the government appears to be right on the line of what is permissible under the law ? in terms of the amount of time involved and possibly the type of questions asked.

However, it?s hard to know how long it will take to get information that may be necessary to protect the public, former prosecutors say.

?It does not seem unreasonable to question Tsarnaev for that period of time,? says Thomas Dupree, a former deputy assistant attorney general and now a partner in Washington law firm of Gibson, Dunn & Crutcher. ?Public safety is paramount here. Law enforcement has to have time to ask questions.?

But 16 hours of questioning seems excessive to Tamar Birckhead, a former federal public defender in Massachusetts and now an associate professor of law at the University of North Carolina at Chapel Hill.

?In the past, it was interpreted as five minutes. Then 50 minutes was found to be fine,? Ms. Birckhead says. ?But 16 hours definitely seems beyond the pale.?

Both sides acknowledge that the so-called public safety exception is vague.

The issue goes back to 1980 when police in the Queens borough of New York received a call that a woman said she had been raped and the suspect was in a supermarket carrying a gun. A police officer ended up apprehending a suspect who had an empty shoulder holster.

After the police officer handcuffed the suspect, he asked him where the gun was. The suspect nodded toward some cartons. The officer retrieved the gun, formally arrested him, and read the man his Miranda rights. The man said that he would answer questions without an attorney present and that he owned the gun.

The trial court excluded the statement and the gun as well as his other statements because of the Miranda violation. This was affirmed by an appeals court. But in 1984, the US Supreme Court overturned the lower courts and said that in this case, public safety (finding the gun) was more important than the Miranda warning.

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/BJVBlPlt0ws/Boston-bombing-interrogation-Will-prosecutors-have-a-Miranda-problem

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Saturday, April 27, 2013

Adaptive Sports and Accessible Recreation Programs

What are adaptive sports and recreation programs??

Adaptive and accessible sports and recreation programs are recreational activities that are modified or designed to allow people with disabilities to participate. Almost any type of recreational activity can be adapted or made accessible for people with physical, visual, cognitive, or emotional disabilities.

Adaptive and accessible sports and recreation programs include a wide range of activities:


  • indoor and outdoor
  • cold weather and warm weather
  • team and individual
  • inclusive and disability-specific
  • for children, for adults, for families
  • for people with physical, intellectual, and/or emotional disabilities
  • competitive and leisure
  • Adaptive and accessible programs give children and adults with disabilities the freedom to participate in mainstream activities, to gain self-confidence, and to develop physical abilities and social skills.

Am I eligible?

Many adaptive and accessible sports and recreation programs are open to everyone. Open programs customize their activities to meet the needs of participants, regardless of the type of disability.

Some programs are disability-specific. Disability-specific programs may limit participation to people with certain types of impairments.

You should check with the programs that interest you to see if they have any restrictions.

How much does it cost?

Many adaptive and accessible sports and recreation programs are free, but some charge fees. Financial aid, scholarships, or sliding fee scales are usually available for families and individuals who need assistance.

You should check with the programs that interest you to see if they charge fees. If they do, ask about financial assistance if you need help paying.

What programs are offered in the state parks and recreation areas?
The Massachusetts Department of Conservation and Recreation (DCR) oversees the state's Universal Access Program. The Universal Access Program provides adaptive and/or accessible outdoor recreation programs for people of all abilities in state parks and recreation areas throughout Massachusetts.

Web site: Department of Conservation and Recreation's Universal Access Program
Parks and programs: Universal Access Brochure
Newsletter: Universal Access Program Newsletter, Registration Form, and Schedule
Schedule of events: Accessible Events



Activities vary from park to park. Programs include adaptive skating, skiing, sledding, and bicycling; accessible beaches with beach wheelchairs; sensory nature walks; accessible trails, fishing sites, camping, and boating; and adventure games. All of the state outdoor swimming pools have pool lifts for accessibility.

For information about specific activities, visit the following DCR web site pages:


?The DCR works together with nonprofit organizations to offer some of the state park adaptive recreation programs.

Where can I find adaptive sports and recreation programs?

The Massachusetts Universal Access Program offers a wide range of activities in state parks and recreation areas.

Other adaptive sports and accessible recreation programs in Massachusetts include:

(Note: For additional programs, see Directories below)

AccesSportAmerica
AccesSportAmerica, a national nonprofit organization based in Massachusetts, offers high-challenge sports and training programs for children and adults of all disabilities. Programs are offered year-round in the Greater Boston area. High-challenge sports include adaptive windsurfing, outrigger canoeing, surfing, water skiing, sailing, rowing, wall climbing, tennis, soccer, and cycling.

All Out Adventures
All Out Adventures is a nonprofit organization that provides year-round outdoor activities for people with disabilities and their friends and family. Programs are inclusive, allowing children and adults of all abilities to participate together. All Out Adventures runs programs for the state Universal Access Program and the Statewide Head Injury Program.

CHD Disability Resources Adaptive Sports and Activities
CHD Disability Resources' barrier-free sports and recreation programs are open to anyone with physical disabilities or visual impairments in the Springfield MA area. Adult and junior sports programs include sled hockey, swimming, cycling, golf, wheelchair basketball, soccer, and more. Adaptive sports equipment is available for borrowing for personal use.

Kids in Disability Sports (K.I.D.S.)
K.I.D.S. is a volunteer-run non-profit organization based in Lowell MA that provides a wide range of sports and recreation activities for children and young adults with special needs. K.I.D.S. specialized athletic programs serve families throughout the Merrimack Valley, and include team sports such as basketball, baseball, and soccer; as well as swimming, horseback riding, martial arts, golf, bowling, and many other activities.

Little League Baseball ? Challenger Division - Massachusetts
The Challenger Division is a special division of Little League baseball for boys and girls with physical and intellectual disabilities, ages 5 through 18 (or completion of high school). Players are placed on teams according to ability, not age, and volunteer ?buddies? help out as needed.n

Paralympics USA and Paralympic Sport Clubs
U.S. Paralympics is the division of the U.S. Olympic Committee for athletes with physical and visual disabilities. The U.S. Paralympic Team participates in the Paralympics, a competition for elite paralympic sport athletes, held at the same time and place as the Olympics.

Paralympic Sport Clubs are community-based programs where youth and adults with physical and visual disabilities can take part in paralympic sports regardless of skill level.

Special Olympics ? Massachusetts (SOMA)
The Massachusetts Special Olympics offers a wide range of Olympic-style individual and team sports and training for children and adults with intellectual disabilities. Activities are year-round, and include Winter Games, Summer Games, special tournaments, and training. The cost is free.

Sudbury Inclusive and Adaptive Sports and Recreation Program?


(not limited to Sudbury residents)
Sudbury's Adaptive Sports and Recreation Program provides year-round affordable recreation activities for children and adults with disabilities, regardless of hometown. Programs include adaptive skiing, skating, fencing, power soccer, yoga, Taekwondo, and dance. Scholarships are available.

TOPSoccer - Massachusetts Youth Soccer?


The Outreach Program for Soccer (TOPSoccer) is a community-based youth soccer program for children with physical or mental disabilities. Each program is different and is designed to meet the needs of its team members. The emphasis is on learning skills and having fun.

Ultimate Sports Program
The Ultimate Sports Program (USP) - "Social Inclusion Through Sports" - teaches sports to children with disabilities alongside their friends. The USP runs programs in various Western Massachusetts locations. All programs are free, and include swimming, basketball, sled hockey, baseball, Taekwondo, wiffleball, bowling, rock climbing, and more.




?

Directories
Other Massachusetts adaptive and accessible sports and recreation programs are listed in the following directories:

Sports and Recreation Directories
?DisabilityInfo.org

Playgrounds: Accessible and Inclusive Playgrounds
Boundless Playgrounds?
Accessible Playgrounds - Massachusetts
Accessible and inclusive playgrounds are barrier-free playgrounds where children and adults of all abilities can play together.

National Center on Physical Activity and Disability (NCPAD) - Massachusetts
Accessible Programs in Massachusetts
Programs are listed by town, or by keyword search. The NCPAD directory includes fitness programs, competitive and leisure sports, and other physical activities, with an emphasis on health benefits of physical activity.

Spinal Cord Injury Association - Greater Boston Chapter
Directory: Recreation and Sports for People with Disabilities
This directory of adaptive programs for youth and adults with spinal cord injuries includes outdoor activities, high-challenge sports, wheelchair basketball, quad rugby, and many other sports and physical activities.

Sports and Gyms, Winter and Summer Activities - Special Needs Resources for Massachusetts
?Sports and Gyms Posts - Summer Programming ? &? Winter Programming
Special Needs Resources for Massachusetts is an online resource for families of children with special needs, with a focus on autism resources in eastern Massachusetts. The Sports and Gyms, Summer Programming, and Winter Programming posts include a variety of current and seasonal sports and recreation programs.

Therapeutic Horsemanship: PATH centers
Directory: PATH: Find a Center
PATH Therapeutic Horsemanship centers offer equine assisted activities and therapies to help children and adults with a range of physical, cognitive, and emotional challenges. Activities include horseback riding, vaulting, and carriage driving. Financial assistance may be available.

Local YMCAs and ARC Chapters also offer adaptive and accessible recreation and sports programs for their members and the community.

?

What are the laws regarding adaptive and accessible sports and recreation?
The federal Americans with Disabilities Act (ADA) prohibits discrimination on the basis of disability. In Recreation Access Rights Under the ADA, the National Center on Accessibility outlines some of the rights created by the ADA with respect to sports and recreation:

  • right to the most integrated setting: People with disabilities and those without disabilities should be able to participate in activities alongside each other to the maximum extent possible
  • right to participate: People with disabilities should be able to take part in any type of activity available to people without disabilities, as long as all essential eligibility requirements are met
  • right to reasonable accommodations including adaptive equipment: The provider of an activity must make reasonable adjustments to allow people with disabilities to participate
  • right to an assessment or evaluation: People with disabilities should not be prohibited from an activity due to a perceived safety risk without an evaluation of actual risk after accommodations
  • no disparate impact: Any change in rules or policies (for example, budget cuts) cannot have a greater impact on people with disabilities than people without disabilities
  • same fees: People with disabilities cannot be charged more than people without disabilities for inclusive activities, whether or not special accommodations have been made
  • no substantial public support for discriminatory programs: State and local governments cannot provide substantial support (e.g. free or reduced cost use of public facilities) to organizations that discriminate based on disability
  • reasonable changes to rules and policies: If a rule or policy change does not fundamentally change the nature of an activity and allows people with disabilities to participate in that activity, then the rule change should be allowed. This includes allowing disability-related unusual behaviors that do not pose a direct threat to participants.
Exceptions to the ADA rules can be made in three cases: if the accommodation costs too much; if the accommodation is too difficult to make; or if the accommodation fundamentally changes the nature of the activity.

The ADA rules apply to government facilities and programs, nonprofit organizations (such as YMCAs), and private organizations (such as health clubs and gyms). The only exempt organizations are private membership clubs and religious organizations.


?To make a donation, please go to www.PVA.org.
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Four die in NATO plane crash in Afghanistan

BERLIN, April 26 (Reuters) - Bayern Munich and Borussia Dortmund striker Robert Lewandowski have not signed a deal, the newly-crowned champions said on Friday, shooting down widespread speculation of another surprise transfer. "Bayern, as opposed to some reports, has no contract with Robert Lewandowski," the Bavarian Champions League semi-finalists said in a brief two-line statement. ...

Source: http://news.yahoo.com/four-die-nato-plane-crash-afghanistan-182134333.html

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NYNE NH-5000


NYNE's latest ?iPod speaker dock, the NH-5000 ($229.95 list) offers an interesting combination of a 30-pin docking connector and wireless Bluetooth capability. That means it works with older Apple devices docked, and newer Android or iOS devices over Bluetooth. The NH-5000 sounds pretty good, too, but a number of questionable design decisions, plus some EQ and distortion issues at higher volumes, keep it from being a top choice.

Design, Connectivity, and Remote
The stylish NH-5000 measures 15.7 by 6.6 by 8 inches (HWD) and weighs 6.5 pounds. It looks more expensive than it is, thanks to its piano black gloss finish, black metal grille, and nicely curved enclosure.?The 30-pin docking connector sits on a hard plastic external protrusion. The NH-5000 is large enough that an iPad docked on it actually looks good, and a small rubberized bumper in the middle of the speaker grille is strong enough to keep everything secure. Plus, the dock connector rotates forward and back on a hinge, so you can pull a device off of the NH-5000 without accidentally snapping off the connector.

Unfortunately, the dock itself doesn't retract. A retractable dock, or at least one that's mostly hidden from view like the one found in the Editors' Choice Bowers & Wilkins Z2, would have made more sense here, given the NH-5000's wireless capabilities. That said, the side of the protruding dock features a 3.5mm auxiliary input, so at least you don't have to reach around the back of the unit to plug in a different kind of MP3 player or cell phone than the dock supports.

The top edge of the NH-5000 features a touch-sensitive control panel with capacitive controls, so you don't feel them when you press down. They include a Power button, a Source select button, and a finicky Volume trackpad that lets you swipe right or left to change volume. I could never get this to work reliably; sometimes it seemed to miss my finger swipes. In a recessed area toward the bottom of the back panel, there's a redundant Power switch, an AC adapter input, a full set of component video outputs, and stereo audio RCA inputs. The video outputs are a nice addition; assuming your HDTV has component video in, you can output any video stored on your iPod, iPad, or iPhone to a large screen while audio plays through the NH-5000.

Pairing via Bluetooth is as simple as can be: Press the Bluetooth button on the remote, and it lights up a flashing Bluetooth icon on the NH-5000's touch-sensitive panel. Search for devices using your device, choose the NYNE NH-5000 when it appears, enter in '0000' for the PIN, and it connects almost instantly.?Power the NH-5000 on, and you'll see a blue LED light up in the bottom right corner of the speaker grille. On top, small white LEDs light up for the selected source and the current volume setting, which increase in number as you turn up the volume. The blue LED also flickers red whenever you press buttons on the remote control, which indicates that it's receiving input.

The included remote control is a thin black slab with a variety of bubbled membrane keys for controlling the NH-5000, including Source, Volume, Track Skip, Play/Pause, Power, Mute, and four EQ modes. The remote doesn't offer playlist control, which is unfortunate. Also in the package: An AC adapter, 3.5mm stereo auxiliary cable, component video out cable, user manual, and Quick Start guide.NYNE NH-5000

Performance and Conclusions
The internal stereo amplifier outputs 25 watts per channel, and features digital signal processing to sculpt the sound. This is a vented enclosure; two bass ports on the back panel, above the extra inputs and outputs, fire backward to increase overall bass response.

About those EQ settings: You get a choice of Movie, Pop, Classic, and Rock settings, with absolutely no explanation in the manual whatsoever, and no indication which one is the default, or most natural-sounding mode. I found the Rock setting to be the most audibly pleasing, and the closest to the way most small speaker docks without configurable EQ are tuned: with a nice bump in the bass response, and a little extra treble emphasis.?Classic seems to be the one that's closest to flat, with less of a smiley EQ curve than the others (which would exaggerate bass and treble response), but it's too harsh for most music thanks to its overly prominent midrange. Pop mode sounds dreadful; it's all upper-midrange boost, which is too harsh even for casual listening. Movie mode boosts low-end extension for bombastic sound effects, and there's a 10kHz treble boost that helps bring out crisp dialog but also sounds unnatural with music.

I tested the NH-5000 with an original Apple iPad docked, and with an iPhone 5 connected via Bluetooth. Flunk's electronic trip-hop track, "Indian Rope Trick," sounded smooth and full, with a nice upper-bass kick drum and a well-rounded sine-wave bass. Rage Against the Machine's "Killing in the Name" sounded powerful and energetic, if a bit strident, and some of the detail I usually hear in the bass guitar's harmonics was MIA; the NH-5000's drivers just aren't that revealing.

Using our standard bass test track, The Knife's "Silent Shout," it was pretty easy to get the NH-5000 to distort. Not so much in Classic mode, but with any of the others, the sound completely fell apart in the low-end as I turned the volume up, even at levels I'd consider reasonable in a small room. This isn't a speaker dock for parties.

In a decidedly crowded field, the NYNE NH-5000 sounds about the way it should for a $230 dock, and its Bluetooth wireless mode adds value, but there are plenty of superior choices.?The Editors' Choice Bowers & Wilkins Z2 speaker dock offers beautifully transparent sound in a slightly smaller enclosure, and also features Apple's new Lightning Connector and AirPlay compatibility, although it costs considerably more and lacks Bluetooth support. The Bose SoundLink Bluetooth Mobile Speaker II, our Editors' Choice for wireless Bluetooth speakers, sounds a bit more neutral, is much smaller, and runs for eight hours on a battery charge, but it doesn't offer the sheer bass oomph of the NH-5000 at lower volumes, and doesn't charge iOS devices either. The Beats by Dr. Dre Beatbox Portable delivers bombastic bass output, offers similar 30-pin docking and Bluetooth wireless capability, and also runs on D-cell batteries, but we weren't thrilled with its audible background hiss, and it's larger and heavier than the NH-5000 as well.

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/6JK0gXj9LBE/0,2817,2418171,00.asp

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Group: Sudan army supporting fugitive warlord Kony

KAMPALA, Uganda (AP) ? The fugitive African warlord Joseph Kony recently found safe haven in territory controlled by Sudan, a watchdog group said Friday, accusing the Sudanese military of offering aid to commanders of the Lord's Resistance Army.

The U.S.-based group Resolve said in a new report that Kony recently directed killings from an enclave protected by the Sudanese military. Until early this year, according to the report, Kony and some of his commanders were operating in Kafia Kingi, a disputed area along the Sudan-South Sudan border where African Union troops tasked with catching Kony don't have access.

"The enclave is currently controlled by Sudan, and numerous eyewitness reports indicate that elements of the Sudanese Armed Forces (SAF) in Kafia Kingi have actively sheltered senior LRA commanders there and provided them with limited material support," the report said. "According to LRA defectors and other sources, LRA leader Joseph Kony himself first traveled to the Kafia Kingi enclave in 2010. He returned to Kafia Kingi in 2011 and was present there throughout parts of 2012."

In a series of makeshift camps near a Sudanese army barracks, Kony "continued to direct LRA attacks against civilians in neighboring countries and issue new orders for LRA fighters."

The Ugandan military ? with support from U.S. military advisers ? is the driving force behind the hunt for Kony. Ugandan army spokesman Col. Felix Kulayigye said the report vindicates Uganda's contention that the LRA is a beneficiary of Sudanese support. Ugandan army officials said late last year they believed Kony was hiding in Sudan-controlled territory, although now they believe he has moved elsewhere.

"We always knew Kony was hiding in Kafia Kingi," he said. "The way forward is that no country should be hiding a wanted criminal."

Kony watchdog groups are concerned that Kony can retreat to Kafia Kingi whenever his pursuers get close. Resolve said it has satellite imagery of the now-abandoned camp where Kony was reportedly seen in late 2012. The warlord is no longer believed to be hiding there, the report noted, saying he may have crossed to Central African Republic.

Sudan has consistently denied charges it supports Kony, a warlord wanted by the International Criminal Court for war crimes and crimes against humanity.

The United States government is evaluating the report that the LRA is operating in the Kafia Kingi region, said State Department spokesman Patrick Ventrell Friday.

"The U.S. and the international community as a whole would take very seriously any credible evidence of support or safe haven being provided to the LRA," said Ventrell, citing a December statement at the U.N. expressing concern about the LRA's possible presence in Kafia Kingi.

"We continue to discuss our concerns about the whereabouts of Joseph Kony with all governments in the region, including with the government of Sudan, and we have encouraged Sudan to cooperate with regional efforts to counter the LRA," Ventrell added. "We're in a position now where two of the top five commanders are gone, the number of people killed by the LRA has gone down by 66 percent, and defections continue. So our pressure on the LRA continues."

Kony's LRA, which originated in Uganda in the 1980s as a popular tribal uprising against the government, has become notorious for recruiting children as fighters and forcing girls to be sex slaves. Military pressure forced the LRA out of Uganda in 2005, and the rebels scattered across parts of central Africa. LRA fighters are now believed to be operating mainly in the jungles of Congo and Central African Republic.

Ugandan Brig. Dick Olum, the top commander of African forces hunting for Kony, recently said he believed Kony had crossed to Central African Republic, where last month rebels deposed a president and expressed hostility toward foreign troops operating in the country. The lack of cooperation from the new government there forced the African Union to suspend military operations against Kony, who over the years has taken advantage of porous borders and weak governments to regroup.

The LRA is vastly diminished from previous years, and its forces now don't exceed 500, according Brig. Olum. Many of Kony's fighters have defected in the past year, and some of his top lieutenants have been captured or killed in combat. Last year an LRA commander believed to be Kony's military strategist was seized by Ugandan troops.

Sudan's support for Kony threatens progress made against the LRA, said the new report by Resolve.

"Unless addressed, it will also enable LRA leaders to outlast current counter-LRA operations," the report said. "Though international diplomats and military officials working to stop LRA attacks privately acknowledge recent LRA movement in Kafia Kingi, they have not adopted realistic strategies to prevent further support from Sudan to Kony's forces."

Source: http://news.yahoo.com/group-sudan-army-supporting-fugitive-warlord-kony-110043174.html

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Friday, April 26, 2013

Rebecca Martinson, Insane Sorority Girl Email Writer, Resigns Over Controversy

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Magic in Veral

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Gut bacteria byproduct predicts heart attack and stroke

Apr. 24, 2013 ? A microbial byproduct of intestinal bacteria contributes to heart disease and serves as an accurate screening tool for predicting future risks of heart attack, stroke and death in persons not otherwise identified by traditional risk factors and blood tests, according to Cleveland Clinic research published today in The New England Journal of Medicine.

The research team was led by Stanley Hazen, M.D., Ph.D., Vice Chair of Translational Research, Chair of the Department of Cellular and Molecular Medicine for the Lerner Research Institute and section head of Preventive Cardiology & Rehabilitation in the Miller Family Heart and Vascular Institute at Cleveland Clinic, and W.H. Wilson Tang, M.D., Department of Cardiovascular Medicine in the Miller Family Heart and Vascular Institute and Lerner Research Institute.

The current study is an extension of Dr. Hazen's previous work, in which he found that a chemical byproduct called trimethylamine N-oxide (TMAO) is produced when intestinal bacteria digest the nutrient phosphatidylcholine, commonly known as lecithin. The prior research showed that TMAO levels in the blood were associated with heart disease. Dr. Hazen and colleagues have now confirmed that gut flora are essential in forming TMAO in humans and demonstrated a relationship between TMAO levels and future cardiac events like heart attack, stroke, and death -- even in those with no prior evidence of cardiac disease risk.

To demonstrate the role of gut flora in forming TMAO, human subjects were asked to eat two hard-boiled eggs (a common dietary source of lecithin) and a capsule of labeled lecithin (as a tracer). After ingestion, TMAO levels in the blood increased. However, when these same subjects were given a brief course of broad-spectrum antibiotics to suppress their gut flora, their TMAO levels were suppressed, and no additional TMAO was formed, even after ingesting lecithin. These results demonstrated that the intestinal bacteria are essential for the formation of TMAO.

In the second phase of the study, the researchers measured TMAO levels in a large, independent, clinical cohort -- consisting of more than 4,000 adults undergoing cardiac evaluation at Cleveland Clinic -- over a three-year follow-up period. They found that higher TMAO blood levels were associated with higher future risks of death and nonfatal heart attack or stroke over the ensuing three-year period, independent of other risk factors and blood test results. These results complement those of another recent study of Dr. Hazen's linking gut flora metabolism of a structurally similar nutrient found in animal products, carnitine, to TMAO production and heart attack risk.

"Heart disease remains the No. 1 killer, and while we know how to reduce cholesterol, treat blood pressure, and reduce cardiac risks through diet and other interventions, a substantial residual risk still remains," Dr. Hazen said. "We need to find new pathways to attack heart disease, and these findings strongly suggest that further research into the involvement of gut microbiome in the development of cardiovascular disease could lead to new avenues of prevention and treatment of heart disease."

Dr. Hazen further suggested, "These studies show that measuring blood levels of TMAO could serve as a powerful tool for predicting future cardiovascular risk, even for those without known risk factors. More studies are needed to confirm that TMAO testing, like cholesterol, triglyceride or glucose levels, might help guide physicians in providing individualized nutritional recommendations for preventing cardiovascular disease. Our goal is not to suggest dietary restrictions of entire food groups. Eggs, meat and other animal products are an integral part of most individuals' diets. Our work shows, however, that when digesting these foods, gut flora can generate a chemical mediator, TMAO, that may contribute to cardiovascular disease."

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The above story is reprinted from materials provided by Cleveland Clinic, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. W.H. Wilson Tang, Zeneng Wang, Bruce S. Levison, Robert A. Koeth, Earl B. Britt, Xiaoming Fu, Yuping Wu, Stanley L. Hazen. Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk. New England Journal of Medicine, 2013; 368 (17): 1575 DOI: 10.1056/NEJMoa1109400

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/D14BpEQC7uQ/130424185211.htm

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Thursday, April 25, 2013

The Engadget Mobile Podcast, live at 2PM ET!

The Engadget Mobile Podcast, live at 2pm ET!

It's the podcast episode you've been waiting a month and a half to hear: the Samsung Galaxy S 4 edition. Now that we've had both in our hands for a considerable amount of time, we're ready to discuss the phone at length, and Joseph Volpe will be joining us for the party. What are its strengths and weaknesses? How does it compare to the Galaxy S III and the HTC One? How many drugs has Myriam ingested in the last 24 hours? We'll do our best to answer these burning questions and more, so listen in at 2PM ET!

April 25, 2013 2:00 PM EDT

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Source: http://www.engadget.com/2013/04/25/engadget-mobile-podcast/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Wednesday, April 24, 2013

To Share or Not to Share - Newsroom

(Illustration by Jamtoons/iStock)

What is it about social media that draws?people in? According to Facebook?s?website, its mission is ?to make the?world more open and connected.?People use Facebook to stay connected?with friends and family, to discover?what?s going on in the world, and to?share and express what matters to them.?

But is this really true? On social media sites, are people really?connected to each other, or merely engaged in an aggregation of?anonymous contacts? While it is true that Facebook?s popularity?has increased exponentially each year?since its inception, many current users censor?what photos and comments they share,?posting only content that positions them in?the best light possible. Yet even with this,?a large amount of personal information is?being made available online that may hinder?your online reputation, as well as aid?marketers in creating targeted advertising?intended to appeal to your interests and?preferences.

Beyond capturing a user?s time and?attention, social media is deemed a safe place?to share one?s innermost thoughts and feelings?for the world ? or at least a large online?audience ? to read. The need for a sense of?community and constant audience often?means users of social media sites such as?Facebook share far more information about?themselves than they reasonably should. Gone is the demand for?privacy. Now, people put their lives on the Internet for all to?see. For Christopher Michaelson, Ph.D., an ?associate professor of?business ethics at the Opus College of Business, this means that?people don?t fully understand the extent to which they are exposing?themselves online.

Today, there is more information available to decision makers?than one can feasibly manage, make sense of or put to use.?What does this mean for marketers? Jonathan Seltzer, an instructor?of marketing at the Opus College of Business, said, ?The sheer?wealth of data that is available increases the segmentation well?beyond what was previously imaginable.? Social media sites and?online networks leverage the power of peer-to-peer relationships?and referrals to learn about their users and make money based on?what they know. ?In theory, better targeting should mean more?efficient marketing for business, and in a consumer economy that?should equate to lower costs and happier customers,? said Michael?Porter, Ed.D., director of the Master of Business Communication?program at the Opus College of Business. But this may not always?be the case.

Information is Power

Not so many years ago, large companies were cautious about?using social media sites to gather information about job applicants?for fear of legal repercussions. Today, it is common practice to?Google an applicant?s name as a way to learn more about past work?history, interests and hobbies, as well as an applicant?s personal?life. Mick Sheppeck, Ph.D., an associate professor of management?at the Opus College of Business, noted, ?Companies are increasingly?using personal information as they?search for qualified applicants and this?is likely to continue until people become?more cognizant of what they are?sharing online and who can access that?information.?

In a January 2013 WCCO segment??Beware: Your Reputation is Now Being?Googled,? Greg Swan, a digital strategist?at Weber Shandwick, noted that 70 percent?of job candidates are rejected purely?based on the results of searching one?s name?online. ?It used to be that you?d ask someone,??Have you Googled yourself lately???and we?d all ?giggle. But now that?s a real?thing,? Swan said.

That?s not to say people are naive?about what they do and don?t share online,?but many do not realize the full extent of?their actions until it?s too late. Generally speaking, social media?users can be broken into two camps in terms of how they think?about personal information and one?s right to privacy. Sheppeck?said the smaller camp believes that access to personal data is the?way of the world. Regardless of safeguards, individuals cannot protect?themselves and should quit worrying. The other, larger camp?needs to pay more attention and be mindful of what they choose?to share. ?Millennials, even more than other groups, are limited in?their awareness of how personal information is being used today,??Sheppeck said.

Targeting the Masses

According to a February 2012 survey by the Pew Research?Center, 73 percent of 2,253 adult respondents answered that they?would not be OK with a search engine (such as Google) keeping?track of their searches and using the results to personalize?future searches. And 68 percent said they were uncomfortable?with targeted advertising for the same reason: They didn?t want?anyone tracking their behavior. That being said, user actions do?not reflect these findings as millions of people routinely share the?most intimate details of their lives online.

When Facebook launched in 2004, it was heralded for its lack?of advertising. With 1 billion active monthly users as of October?2012, a lot has changed since its founding. The ?average Facebook?user is regularly commenting on photos and ?liking? content,?updating their status and connecting with friends and family, as?well as those they?ve never met. While no stranger to advertising,?the average Facebook user may not realize how her information?is being used to generate the targeted ads she sees every time?she logs in. If you recently became engaged, the ads are tailored?accordingly and may include bridesmaid dresses, photographers,?upcoming wedding shows and invitations, with many products?and vendors showing up as promoted posts in a user?s news feed.?Once you update your status to reflect your recent nuptials, the?ads will change again, likely ?focusing on the next logical step after?that blissful walk down the aisle ? the?honeymoon followed by babies.

For those looking to advertise with?Facebook, the online social giant leverages?its more than 1 billion users, saying,??We?ll help you reach the right ones.??But what does that mean? Every piece?of information shared on Facebook says?something about a user. Individually,?those pieces of information aren?t much,?but together they tell a very complete?story about each user?s personal life,?education and work experience, likes and?hobbies, and much more. By targeting a?group based on location, age and likes,?marketers can reach a very specific segment?of their target audience and one?that is likely to be receptive to the message?being communicated.

Facebook?s primary source of revenue?is advertising. By selecting key?words and personal information shared by each user ? such as relationship?status, location, employment, likes and activities ? businesses?can run ads targeting a selected subset of users. A February?2012 article on the New York Times opinion page stated that?Facebook earned $3.2 billion in advertising revenue in 2011,?which makes up 85 percent of its total revenue.

The same article noted Google?s use of personal data for?advertising and its resulting $36.5 billion in advertising revenue?in 2011. By simply ?analyzing what people sent ?over Gmail and?what they searched on the Web,? Google obtains a mass of data?and information to sell ads, markedly more information than even?Facebook, given that Google is one of the most popular search?engines used today.

A Right to Privacy

According to Porter, ?There is a balance that consumers need?to accept between privacy and free services as a part of the economic?exchange.? As consumers, your buying habits and purchases?provide information about you, and retailers would be foolish to?ignore this information, but at what point does it cross the line??To that end, Sheppeck raised several interesting questions:??How much data is too much? Where should companies draw the?line when it comes to mining for customer information? If privacy?is the number one concern, at what point is an individual?s privacy?breeched??

Additionally, Sheppeck added, the mere act of tracking and?storing personal data puts that data at risk and, therefore, puts?individual privacy at risk. If the practice of mining?personal information is to continue with?little or no legislation regulating it there must?be safeguards in place to protect said data. While?breeches of security are to be expected, consumers?expect that personal information will be protected?in addition to being leveraged.

What the Future Holds

With far more questions than answers, this?issue is just starting to heat up. As users of social?media start at a younger age and people become?more conscious of how their personal information?is being used, as well as how it impacts?their online reputation and subsequent ability?to get a job, the legal ramifications will start?coming to light. ?Right now, the economy is?our primary concern. As the economy improves?or at least stabilizes, issues regarding user privacy?and how personal information is managed?will find their way into the courtroom, and the?resulting legislation will better safeguard the personal data being?shared online,? Sheppeck said. ?In the near future, we will need?a federal standard that articulates data areas that are off limits.?

Until then, users must be vigilant about what they do and?don?t share online. It often is forgotten that the Internet lives on.?You may delete a post or picture, but ?somewhere, on some far?distant server, there is a record of you at last year?s office party?with a lampshade on your head.

Read more from B. Magazine.

Source: http://www.stthomas.edu/news/2013/04/23/to-share-or-not-to-share/

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Tsarnaev's name was in terrorism database

WASHINGTON (AP) ? The federal government added the name of the dead Boston Marathon bombing suspect to a terrorist database 18 months before the deadly explosions, U.S. officials told The Associated Press on Wednesday.

The CIA made the request to add Tamerlan Tsarnaev's name to the terrorist database after the Russian government contacted the agency with concerns that he had become a follower of radical Islam. About six months earlier, the FBI had separately investigated Tsarnaev, also at Russia's request, but the FBI found no ties to terrorism, officials said.

The new disclosure that Tsarnaev was included within a huge, classified database of known and suspected terrorists before the attacks was expected to drive congressional inquiries in coming weeks about whether the Obama administration adequately investigated tips from Russia that Tsarnaev had posed a security threat. Shortly after the bombings, U.S. officials said the intelligence community had no information about threats to the marathon before the April 15 explosions.

Tsarnaev died Friday in a police shootout hours before his younger brother, Dzhokhar, was discovered hiding in a boat in a suburban back yard.

The terrorist database is called TIDE, the Terrorist Identities Datamart Environment. Analysts at the U.S. National Counterterrorism Center submit names and even partial names into TIDE. About a year ago, there were some 745,000 people listed in the database. Intelligence analysts scour TIDE, trying to establish connections and update files as new intelligence is uncovered.

For entries with a full name, date of birth and intelligence indicating a reasonable suspicion that a person is a terrorist or has terror ties, the person's name is sent to a terror watch list, which feeds into lists like the one that bans known or suspected terrorists from traveling on planes.

Officials say they never found the type of derogatory information on Tsarnaev that would have elevated his profile among counterterrorism investigators and placed him on the terror watch list.

Five days after the U.S. determined who was allegedly behind the deadly Boston marathon terror attacks, Washington is piecing together what happened and whether there were any unconnected dots buried in U.S. government files that, if connected, could have prevented the bombings.

Lawmakers who were briefed by the FBI said they have more questions than answers about the investigation of Tsarnaev. U.S. officials were expected to brief the Senate on the investigation Thursday.

This combination of undated file photos shows Tamerlan Tsarnaev, 26, left, and Dzhokhar Tsarnaev, 19. The FBI says the two brothers are the suspects in the Boston Marathon bombing, and are also ... more? This combination of undated file photos shows Tamerlan Tsarnaev, 26, left, and Dzhokhar Tsarnaev, 19. The FBI says the two brothers are the suspects in the Boston Marathon bombing, and are also responsible for killing an MIT police officer, critically injuring a transit officer in a firefight and throwing explosive devices at police during a getaway attempt in a long night of violence that left Tamerlan dead and Dzhokhar captured, late Friday, April 19, 2013. Tamerlan and Dzhokhar Tsarnaev sought to embrace American lives after immigrating from Russia _ joining a boxing club, winning a scholarship and even seeking U.S. citizenship. But their uncle last week angrily called them ?losers? who failed to feel settled even after a decade of living in the United States. (AP Photo/The Lowell Sun & Robin Young, File) less? ?

"The review is just beginning, but I haven't seen any red flags thus far," said Rep. Adam Schiff, a California Democrat who sits on the House Intelligence Committee and was briefed on the investigation Wednesday. House Judiciary Chairman Bob Goodlatte, R-Va., however, said lawmakers intend to pursue whether there was a breakdown in information-sharing.

U.S. officials described to the AP what the government knew about Tsarnaev since he was first placed on the intelligence community's radar 18 months ago. The officials spoke on condition of anonymity because they were not authorized to publicly discuss the ongoing investigation.

Russia's internal security service, the FSB, sent information to the FBI about Tamerlan Tsarnaev on March 4, 2011. The Russians told the FBI that Tsarnaev, an ethnically Chechen Russian immigrant living in the Boston area, was a follower of radical Islam and had changed drastically since 2010. Because of the subsequent FBI inquiry, Tsarnaev's name was added to a Homeland Security Department database used by U.S. officials at the border to help screen people coming in and out of the U.S. That database is called the Treasury Enforcement Communications System, or TECS.

The FBI's Boston office opened a preliminary review of Tsarnaev and searched government databases for potentially terror-related communications. Investigators looked into whether Tsarnaev used online sites that promoted radical activity. They interviewed Tsarnaev and his family members but found nothing connecting him to terror activity. The FBI shared that information with Russia and also asked for more information on Tsarnaev, but never heard back. The FBI's review into Tsarnaev was closed in June 2011.

Then, in late September 2011, Russia separately contacted the CIA with nearly identical concerns about Tsarnaev. The Russians provided two possible birthdates for him and a variation of how his name might be spelled, as well as the spelling in the Russian-style Cyrillic alphabet.

The CIA determined that Tsarnaev should be included in TIDE, and the National Counterterrorism Center added it into the database. The spelling of Tsarnaev's name in TIDE was not the same as the spelling the FBI used in its investigation. The CIA also shared this information with other federal agencies in October.

In January 2012, Tsarnaev traveled to Russia and returned to the U.S. in July. Three days before he left for Russia, the TECS database generated an alert on Tsarnaev. That alert was shared with a Customs and Border Protection officer who is a member of the FBI's Boston joint terrorism task force. By that time, the FBI's investigation into Tsarnaev had been closed for nearly six months because the FBI uncovered no evidence that he was tied to terror groups.

On Jan. 21, 2012, the airline on which Tsarnaev was traveling misspelled his name when it submitted its list of passengers to the U.S. government for security screening. Airlines are required to provide the list of passengers on international flights so the U.S. can check their names through government databases, including the terrorist watch list. Because his name was misspelled, there was not another alert like there was three days earlier.

In July 2012, Tsarnaev returned to the U.S., and another alert was generated in TECS. This information was again shared with the Customs and Border Protection officer on the FBI's Boston joint terrorism task force. But because the FBI had closed its investigation into Tsarnaev a year earlier, there was no reason to be suspicious of his travels to Russia.

"Later on, these agencies will be judged," said Dutch Ruppersberger of Maryland, the top Democrat on the House Intelligence Committee. "But right now, it's way too soon to criticize or to start making political arguments or who failed or whatever."

___

Associated Press writer Pete Yost contributed to this report.

___

Follow Eileen Sullivan on Twitter: http://twitter.com/esullivanap

Source: http://news.yahoo.com/officials-dead-bomber-name-terrorism-database-224317195.html

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Scientists map all possible drug-like chemical compounds

Tuesday, April 23, 2013

Drug developers may have a new tool to search for more effective medications and new materials.

It's a computer algorithm that can model and catalogue the entire set of lightweight, carbon-containing molecules that chemists could feasibly create in a lab.

The small-molecule universe has more than 10^60 (that's 1 with 60 zeroes after it) chemical structures. Duke chemist David Beratan said that many of the world's problems have molecular solutions in this chemical space, whether it's a cure for disease or a new material to capture sunlight.

But, he said, "The small-molecule universe is astronomical in size. When we search it for new molecular solutions, we are lost. We don't know which way to look."

To give synthetic chemists better directions in their molecular search, Beratan and his colleagues -- Duke chemist Weitao Yang, postdoctoral associates Aaron Virshup and Julia Contreras-Garcia, and University of Pittsburgh chemist Peter Wipf -- designed a new computer algorithm to map the small-molecule universe.

The map, developed with a National Institutes of Health P50 Center grant, tells scientists where the unexplored regions of the chemical space are and how to build structures to get there. A paper describing the algorithm and map appeared online in April in the Journal of the American Chemical Society.

The map helps chemists because they do not yet have the tools, time or money to synthesize all 10^60 compounds in the small-molecule universe. Synthetic chemists can only make a few hundred or a few thousand molecules at a time, so they have to carefully choose which compounds to build, Beratan said.

The scientists already have a digital library describing about a billion molecules found in the small-molecule universe, and they have synthesized about 100 million compounds over the course of human history, Beratan said. But these molecules are similar in structure and come from the same regions of the small-molecule universe.

It's the unexplored regions that could hold molecular solutions to some of the world's most vexing challenges, Beratan said.

To add diversity and explore new regions to the chemical space, Aaron Virshup developed a computer algorithm that built a virtual library of 9 million molecules with compounds representing every region of the small-molecule universe.

"The idea was to start with a simple molecule and make random changes, so you add a carbon, change a double bond to a single bond, add a nitrogen. By doing that over and over again, you can get to any molecule you can think of," Virshup said.

He programed the new algorithm to make small, random chemical changes to the structure of benzene and then to catalogue the new molecules it created based on where they fit into the map of the small-molecule universe. The challenge, Virshup said, came in identifying which new chemical compounds chemists could actually create in a lab.

Virshup sent his early drafts of the algorithm's newly constructed molecules to synthetic chemists who scribbled on them in red ink to show whether they were synthetically unstable or unrealistic. He then turned the criticisms into rules the algorithm had to follow so it would not make those types of compounds again.

"The rules kept us from getting lost in the chemical space," he said.

After ten iterations, the algorithm finally produced 9 million synthesizable molecules representing every region of the small-molecule universe, and it produced a map showing the regions of the chemical space where scientists have not yet synthesized any compounds.

"With the map, we can tell chemists, if you can synthesize a new molecule in this region of space, you have made a new type of compound," Virshup said. "It's an intellectual property issue. If you're in the blank spaces on our small molecule map, you're guaranteed to make something that isn't patented yet," he said.

The team has made the source code for the algorithm available online. The researchers said they hope scientists will use it to immediately start mining the unexplored regions of the small molecule universe for new chemical compounds.

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Duke University: http://www.duke.edu

Thanks to Duke University for this article.

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Source: http://www.labspaces.net/127863/Scientists_map_all_possible_drug_like_chemical_compounds

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